Received: JanuAccepted: JPublished: July 27, 2020Ĭopyright: © 2020 Park, Geffen. Theunissen, University of California at Berkeley, UNITED STATES PLoS Comput Biol 16(7):Įditor: Frédéric E. This approach brings together multiple findings from different laboratories and identifies a circuit that can be used in future studies of upstream and downstream sensory processing.Ĭitation: Park Y, Geffen MN (2020) A circuit model of auditory cortex. This circuit exhibits a balance of inhibitory and excitatory currents that persists on stimulation. These roles reproduce the differential effects of PVs and SSTs in stimulus-specific adaptation, forward suppression and tuning-curve adaptation, as well as the influence of PVs on feedforward functional connectivity in the circuit. These roles are augmented by plastic synapses. Second, SSTs are generally disinhibited by reduced PV activity regardless of thalamic input strength. First, PVs compensate for reduced SST activity when thalamic inputs are strong with less compensation when thalamic inputs are weak. By starting with a cortical rate model, we find that a simple current-compensating mechanism accounts for the experimental findings from multiple groups. Specifically, we asked whether a common microcircuit can account for the disparate effects found in studies by different groups. These studies can inform our understanding of parameters for the connectivity of excitatory-inhibitory cortical circuits. Recent studies found that two most common inhibitory interneurons, parvalbumin- (PV) and somatostatin-(SST) positive interneurons control sound-evoked responses, temporal adaptation and network dynamics in the auditory cortex (AC). Despite rapid progress in understanding the function of distinct neuronal populations, the parameters of connectivity that are required for the function of these microcircuits remain unknown. The mammalian sensory cortex is composed of multiple types of inhibitory and excitatory neurons, which form sophisticated microcircuits for processing and transmitting sensory information.
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